Exploring Primary Liver Macrophages for Studying Quantum Dot Interactions with Biological Systems

Hans C Fischer, Tanya S Hauck, Alejandro Gómez‐Aristizábal, Warren CW Chan

Advanced Materials, Volume 22, Issue 23 | DOI: 10.1002/adma.200904231


The effect quantum dots have on primary rat macrophages is investigated, and the findings are compared to in vivo data. In vitro uptake kinetics and degradation both reflect in vivo findings; therefore, primary macrophages are shown to be an appropriate system with which to investigate cellular responses to quantum dots and other nanoparticles in order to guide in vivo studies.