A Plasmonic DNAzyme Strategy for Point‐of‐Care Genetic Detection of Infectious Pathogens

Kyryl Zagorovsky, Warren CW Chan

Angewandte Chemie International Edition, Volume 52, Issue 11 | DOI: 10.1002/anie.201208715


Always use detection: Signal amplification from DNAzymes (see scheme) was combined with gold nanoparticles (GNPs) to give a simple and sensitive colorimetric assay for various genetic targets. The assay has 50 pM sensitivity without the need for purification steps and can detect multiple targets in parallel. This was applied to rapidly detect gonorrhea, syphilis, malaria, and hepatitis B infections.